Drug interactions
Berotralstat + Paliperidone
Severity: Moderate
Berotralstat and Paliperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Berotralstat inhibits P-glycoprotein, and paliperidone is a P-gp substrate, so paliperidone exposure may rise. This may increase dose-related adverse effects such as sedation, extrapyramidal symptoms and QT prolongation.
What this interaction means in plain words
Berotralstat and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Berotralstat belongs to Miscellaneous; Paliperidone belongs to Central Nervous System.
Why it happens
Inhibition of P-glycoprotein efflux by berotralstat increases paliperidone absorption and reduces its clearance.
What to do
Monitor for paliperidone adverse effects, including EPS and QT prolongation, and reduce the paliperidone dose if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Other interactions of Berotralstat
- Berotralstat + Ergotamine Major
- Berotralstat + Nilotinib Major
- Berotralstat + Pimozide Major
- Berotralstat + Quinidine Major
- Berotralstat + Quinine Major
- Berotralstat + Tacrolimus Major
Frequently asked questions
Can I take Berotralstat with Paliperidone?
MediHelp rates the interaction as moderate. Berotralstat and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Berotralstat inhibits P-glycoprotein, and paliperidone is a P-gp substrate, so paliperidone exposure may rise. This may increase dose-related adverse effects such as sedation, extrapyramidal symptoms and QT prolongation.
How serious is the interaction between Berotralstat and Paliperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for paliperidone adverse effects, including EPS and QT prolongation, and reduce the paliperidone dose if they occur.
What other medicines interact with Paliperidone?
MediHelp also lists interactions of Paliperidone with, for example, Ibutilide, Pimozide, Vandetanib. The full list is on the Paliperidone page.
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