Drug interactions
Berotralstat + Pravastatin
Severity: Minor
Berotralstat and Pravastatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Berotralstat inhibits P-gp and could modestly raise pravastatin exposure. The effect is generally small, but higher statin levels may raise the chance of muscle symptoms.
What this interaction means in plain words
Berotralstat and Pravastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Berotralstat belongs to Miscellaneous; Pravastatin belongs to Cardiovascular.
Why it happens
Berotralstat inhibits P-glycoprotein, reducing pravastatin efflux.
What to do
No routine dose change; monitor for myalgia and adjust the pravastatin dose if symptoms occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pravastatin
Other interactions of Berotralstat
- Berotralstat + Ergotamine Major
- Berotralstat + Nilotinib Major
- Berotralstat + Pimozide Major
- Berotralstat + Quinidine Major
- Berotralstat + Quinine Major
- Berotralstat + Tacrolimus Major
Frequently asked questions
Can I take Berotralstat with Pravastatin?
MediHelp rates the interaction as minor. Berotralstat and Pravastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Berotralstat inhibits P-gp and could modestly raise pravastatin exposure. The effect is generally small, but higher statin levels may raise the chance of muscle symptoms.
How serious is the interaction between Berotralstat and Pravastatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change; monitor for myalgia and adjust the pravastatin dose if symptoms occur.
What other medicines interact with Pravastatin?
MediHelp also lists interactions of Pravastatin with, for example, Cyclosporine, Cyclosporin, Gemfibrozil. The full list is on the Pravastatin page.
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