Drug interactions
Berotralstat + Rimegepant
Severity: Moderate
Berotralstat and Rimegepant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Berotralstat inhibits P-glycoprotein, and rimegepant is a P-gp substrate, so rimegepant exposure may increase. Rimegepant labeling advises avoiding a second dose within 48 hours when it is taken with P-gp inhibitors.
What this interaction means in plain words
Berotralstat and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Berotralstat belongs to Miscellaneous; Rimegepant belongs to Central Nervous System.
Why it happens
Inhibition of intestinal and cellular P-glycoprotein efflux by berotralstat raises rimegepant absorption and plasma concentrations.
What to do
Avoid taking a second rimegepant dose within 48 hours of the first when used with berotralstat. Monitor for increased adverse effects such as nausea and hypersensitivity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rimegepant
Other interactions of Berotralstat
- Berotralstat + Ergotamine Major
- Berotralstat + Nilotinib Major
- Berotralstat + Pimozide Major
- Berotralstat + Quinidine Major
- Berotralstat + Quinine Major
- Berotralstat + Tacrolimus Major
Frequently asked questions
Can I take Berotralstat with Rimegepant?
MediHelp rates the interaction as moderate. Berotralstat and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Berotralstat inhibits P-glycoprotein, and rimegepant is a P-gp substrate, so rimegepant exposure may increase. Rimegepant labeling advises avoiding a second dose within 48 hours when it is taken with P-gp inhibitors.
How serious is the interaction between Berotralstat and Rimegepant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid taking a second rimegepant dose within 48 hours of the first when used with berotralstat. Monitor for increased adverse effects such as nausea and hypersensitivity.
What other medicines interact with Rimegepant?
MediHelp also lists interactions of Rimegepant with, for example, Amobarbital, Atazanavir, Butabarbital. The full list is on the Rimegepant page.
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