Drug interactions
Berotralstat + Saxagliptin
Severity: Minor
Berotralstat and Saxagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Berotralstat inhibits P-glycoprotein and CYP3A4, and saxagliptin is a CYP3A4/5 and P-gp substrate, so saxagliptin exposure may rise. The increase is likely modest and saxagliptin has a wide margin.
What this interaction means in plain words
Berotralstat and Saxagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Berotralstat belongs to Miscellaneous; Saxagliptin belongs to Endocrine.
Why it happens
P-glycoprotein and CYP3A4 inhibition by berotralstat reduces saxagliptin efflux and metabolism.
What to do
Monitor for saxagliptin adverse effects and renal function. Dose adjustment is generally unnecessary.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Saxagliptin
- Albiglutide + Saxagliptin Moderate
- Amlodipine-benazepril + Saxagliptin Moderate
- Aripiprazole + Saxagliptin Moderate
- Asenapine + Saxagliptin Moderate
- Atazanavir + Saxagliptin Moderate
- Benazepril + Saxagliptin Moderate
Other interactions of Berotralstat
- Berotralstat + Ergotamine Major
- Berotralstat + Nilotinib Major
- Berotralstat + Pimozide Major
- Berotralstat + Quinidine Major
- Berotralstat + Quinine Major
- Berotralstat + Tacrolimus Major
Frequently asked questions
Can I take Berotralstat with Saxagliptin?
MediHelp rates the interaction as minor. Berotralstat and Saxagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Berotralstat inhibits P-glycoprotein and CYP3A4, and saxagliptin is a CYP3A4/5 and P-gp substrate, so saxagliptin exposure may rise. The increase is likely modest and saxagliptin has a wide margin.
How serious is the interaction between Berotralstat and Saxagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for saxagliptin adverse effects and renal function. Dose adjustment is generally unnecessary.
What other medicines interact with Saxagliptin?
MediHelp also lists interactions of Saxagliptin with, for example, Albiglutide, Amlodipine-benazepril, Aripiprazole. The full list is on the Saxagliptin page.
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