Drug interactions
Berotralstat + Sofosbuvir-velpatasvir-voxilaprevir
Severity: Moderate
Berotralstat and Sofosbuvir-velpatasvir-voxilaprevir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Berotralstat inhibits P-glycoprotein and may raise exposure to velpatasvir, voxilaprevir and sofosbuvir, which are P-gp substrates. The combination may also raise berotralstat levels through transporter effects. The increases are usually modest and manageable.
What this interaction means in plain words
Berotralstat and Sofosbuvir-velpatasvir-voxilaprevir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Berotralstat belongs to Miscellaneous; Sofosbuvir-velpatasvir-voxilaprevir belongs to Anti Virals.
Why it happens
Mutual inhibition of P-glycoprotein (and possibly other transporters) reduces efflux and increases systemic exposure of the substrates.
What to do
Coadminister with monitoring for adverse effects of both products, including berotralstat GI effects and QT-related symptoms. Consider ECG monitoring if the patient has other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sofosbuvir-velpatasvir-voxilaprevir
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenobarbital + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifampin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Other interactions of Berotralstat
- Berotralstat + Ergotamine Major
- Berotralstat + Nilotinib Major
- Berotralstat + Pimozide Major
- Berotralstat + Quinidine Major
- Berotralstat + Quinine Major
- Berotralstat + Tacrolimus Major
Frequently asked questions
Can I take Berotralstat with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp rates the interaction as moderate. Berotralstat and Sofosbuvir-velpatasvir-voxilaprevir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Berotralstat inhibits P-glycoprotein and may raise exposure to velpatasvir, voxilaprevir and sofosbuvir, which are P-gp substrates. The combination may also raise berotralstat levels through transporter effects. The increases are usually modest and manageable.
How serious is the interaction between Berotralstat and Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Coadminister with monitoring for adverse effects of both products, including berotralstat GI effects and QT-related symptoms. Consider ECG monitoring if the patient has other QT risk factors.
What other medicines interact with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir-voxilaprevir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Sofosbuvir-velpatasvir-voxilaprevir page.
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