Drug interactions
Betaxolol + Digoxin
Severity: Moderate
Betaxolol and Digoxin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs slow AV nodal conduction, so the combination can cause bradycardia and heart block. Effects are most pronounced in older patients or those with conduction disease.
What this interaction means in plain words
Betaxolol and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Betaxolol belongs to Cardiovascular; Digoxin belongs to Cardiovascular.
Why it happens
Additive depression of sinus and AV node function via beta-blockade and vagotonic digoxin effect.
What to do
Monitor heart rate and ECG, particularly at initiation or dose changes. Adjust doses or stop one drug if significant bradycardia or block occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Betaxolol
- Acebutolol + Betaxolol Major
- Aldesleukin + Betaxolol Major
- Amifostine + Betaxolol Major
- Amiodarone + Betaxolol Major
- Atenolol-chlorthalidone + Betaxolol Major
- Atenolol + Betaxolol Major
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Betaxolol with Digoxin?
MediHelp rates the interaction as moderate. Betaxolol and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs slow AV nodal conduction, so the combination can cause bradycardia and heart block. Effects are most pronounced in older patients or those with conduction disease.
How serious is the interaction between Betaxolol and Digoxin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and ECG, particularly at initiation or dose changes. Adjust doses or stop one drug if significant bradycardia or block occurs.
What other medicines interact with Betaxolol?
MediHelp also lists interactions of Betaxolol with, for example, Acebutolol, Aldesleukin, Amifostine. The full list is on the Betaxolol page.
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