Drug interactions
Betaxolol + Dihydroergotamine
Severity: Moderate
Betaxolol and Dihydroergotamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dihydroergotamine is a vasoconstrictor and beta blockers may add to peripheral vasoconstriction by leaving alpha effects unopposed. Reduced limb perfusion, cold extremities or ischemia are possible, especially with high ergot exposure. Risk is greater with ergotamine than with dihydroergotamine.
What this interaction means in plain words
Betaxolol and Dihydroergotamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Betaxolol belongs to Cardiovascular; Dihydroergotamine belongs to Central Nervous System.
Why it happens
Additive vasoconstriction through ergot-mediated vasospasm and unopposed alpha-adrenergic tone under beta blockade.
What to do
Monitor for cold extremities, paresthesia or claudication. Stop dihydroergotamine if signs of peripheral ischemia appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Betaxolol
- Acebutolol + Betaxolol Major
- Aldesleukin + Betaxolol Major
- Amifostine + Betaxolol Major
- Amiodarone + Betaxolol Major
- Atenolol-chlorthalidone + Betaxolol Major
- Atenolol + Betaxolol Major
Other interactions of Dihydroergotamine
- Almotriptan + Dihydroergotamine Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
- Dihydroergotamine + Dopamine Contraindicated
- Dihydroergotamine + Dronedarone Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Dihydroergotamine + Eletriptan Contraindicated
Frequently asked questions
Can I take Betaxolol with Dihydroergotamine?
MediHelp rates the interaction as moderate. Betaxolol and Dihydroergotamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dihydroergotamine is a vasoconstrictor and beta blockers may add to peripheral vasoconstriction by leaving alpha effects unopposed. Reduced limb perfusion, cold extremities or ischemia are possible, especially with high ergot exposure. Risk is greater with ergotamine than with dihydroergotamine.
How serious is the interaction between Betaxolol and Dihydroergotamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for cold extremities, paresthesia or claudication. Stop dihydroergotamine if signs of peripheral ischemia appear.
What other medicines interact with Betaxolol?
MediHelp also lists interactions of Betaxolol with, for example, Acebutolol, Aldesleukin, Amifostine. The full list is on the Betaxolol page.
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