Drug interactions
Betrixaban + Canagliflozin
Severity: Moderate
Betrixaban and Canagliflozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Canagliflozin is a weak P-glycoprotein inhibitor and may increase exposure to betrixaban, a P-gp substrate. Higher betrixaban levels can raise bleeding risk.
What this interaction means in plain words
Betrixaban and Canagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of P-glycoprotein efflux transport by canagliflozin reduces betrixaban efflux and increases its systemic exposure.
What to do
Monitor for signs of bleeding. Follow betrixaban labeling for reduced dosing when used with P-gp inhibitors if the interaction is considered clinically relevant.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Canagliflozin
Frequently asked questions
Can I take Betrixaban with Canagliflozin?
MediHelp rates the interaction as moderate. Betrixaban and Canagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Canagliflozin is a weak P-glycoprotein inhibitor and may increase exposure to betrixaban, a P-gp substrate. Higher betrixaban levels can raise bleeding risk.
How serious is the interaction between Betrixaban and Canagliflozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding. Follow betrixaban labeling for reduced dosing when used with P-gp inhibitors if the interaction is considered clinically relevant.
What other medicines interact with Canagliflozin?
MediHelp also lists interactions of Canagliflozin with, for example, Aliskiren, Amiloride, Amlodipine-benazepril. The full list is on the Canagliflozin page.
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