Drug interactions
Betrixaban + Everolimus
Severity: Moderate
Betrixaban and Everolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Everolimus is a P-glycoprotein inhibitor and may raise betrixaban exposure, increasing bleeding risk. Betrixaban labeling calls for dose reduction with P-gp inhibitors.
What this interaction means in plain words
Betrixaban and Everolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Everolimus inhibits P-glycoprotein, reducing efflux of betrixaban.
What to do
Use the reduced betrixaban dosing recommended for P-gp inhibitors and monitor for bleeding. Consider an alternative anticoagulant if bleeding risk is high.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Frequently asked questions
Can I take Betrixaban with Everolimus?
MediHelp rates the interaction as moderate. Betrixaban and Everolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Everolimus is a P-glycoprotein inhibitor and may raise betrixaban exposure, increasing bleeding risk. Betrixaban labeling calls for dose reduction with P-gp inhibitors.
How serious is the interaction between Betrixaban and Everolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the reduced betrixaban dosing recommended for P-gp inhibitors and monitor for bleeding. Consider an alternative anticoagulant if bleeding risk is high.
What other medicines interact with Everolimus?
MediHelp also lists interactions of Everolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Levoketoconazole. The full list is on the Everolimus page.
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