Drug interactions
Betrixaban + Vortioxetine
Severity: Moderate
Betrixaban and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Betrixaban is a factor Xa inhibitor that raises bleeding risk, and serotonergic antidepressants impair platelet aggregation. Together they may increase the likelihood of clinically significant bleeding.
What this interaction means in plain words
Betrixaban and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hemostatic effects: factor Xa inhibition plus SSRI-like impairment of platelet function.
What to do
Monitor for bleeding and check hemoglobin periodically, especially in older patients or those with renal impairment. Reassess the need for both drugs if bleeding occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Frequently asked questions
Can I take Betrixaban with Vortioxetine?
MediHelp rates the interaction as moderate. Betrixaban and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Betrixaban is a factor Xa inhibitor that raises bleeding risk, and serotonergic antidepressants impair platelet aggregation. Together they may increase the likelihood of clinically significant bleeding.
How serious is the interaction between Betrixaban and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and check hemoglobin periodically, especially in older patients or those with renal impairment. Reassess the need for both drugs if bleeding occurs.
What other medicines interact with Vortioxetine?
MediHelp also lists interactions of Vortioxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Vortioxetine page.
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