Drug interactions
Bevacizumab + Irinotecan
Severity: Moderate
Bevacizumab and Irinotecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bevacizumab is routinely combined with irinotecan regimens, but the combination can increase diarrhea, neutropenia and dehydration. Bevacizumab also adds risks such as gastrointestinal perforation and bleeding.
What this interaction means in plain words
Bevacizumab and Irinotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bevacizumab belongs to Oncology; Irinotecan belongs to Oncology.
Why it happens
Additive pharmacodynamic toxicity; no major pharmacokinetic interaction is established.
What to do
Monitor blood counts, hydration and bowel function, treating diarrhea promptly and adjusting irinotecan dose for severe toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bevacizumab
- Bevacizumab + Sunitinib Major
- Bevacizumab + Daunorubicin Moderate
- Bevacizumab + Dengue vaccine Moderate
- Bevacizumab + Doxorubicin Moderate
- Bevacizumab + Doxorubicin liposomal Moderate
- Bevacizumab + Efgartigimod / hyaluronidase sc Moderate
Other interactions of Irinotecan
- Clozapine + Irinotecan Contraindicated
- Irinotecan + Sacituzumab govitecan Contraindicated
- Adenovirus types 4 and 7 live + Irinotecan Major
- Apalutamide + Irinotecan Major
- Atazanavir + Irinotecan Major
- Carbamazepine + Irinotecan Major
Frequently asked questions
Can I take Bevacizumab with Irinotecan?
MediHelp rates the interaction as moderate. Bevacizumab and Irinotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bevacizumab is routinely combined with irinotecan regimens, but the combination can increase diarrhea, neutropenia and dehydration. Bevacizumab also adds risks such as gastrointestinal perforation and bleeding.
How serious is the interaction between Bevacizumab and Irinotecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts, hydration and bowel function, treating diarrhea promptly and adjusting irinotecan dose for severe toxicity.
What other medicines interact with Bevacizumab?
MediHelp also lists interactions of Bevacizumab with, for example, Sunitinib, Daunorubicin, Dengue vaccine. The full list is on the Bevacizumab page.
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