Drug interactions
Bevacizumab + Sorafenib
Severity: Moderate
Bevacizumab and Sorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining bevacizumab with sorafenib has been associated with a higher frequency and severity of hand-foot skin reaction and also with additive hypertension and bleeding risk. This can limit tolerability and force dose reductions or interruption of therapy.
What this interaction means in plain words
Bevacizumab and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bevacizumab belongs to Oncology; Sorafenib belongs to Oncology.
Why it happens
Both agents inhibit VEGF signaling, producing overlapping toxicities (skin, vascular and blood pressure effects), so the effects are additive pharmacodynamically.
What to do
Examine hands and feet regularly and monitor blood pressure at each visit. Reduce or hold sorafenib for significant skin toxicity and treat hypertension promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bevacizumab
- Bevacizumab + Sunitinib Major
- Bevacizumab + Daunorubicin Moderate
- Bevacizumab + Dengue vaccine Moderate
- Bevacizumab + Doxorubicin Moderate
- Bevacizumab + Doxorubicin liposomal Moderate
- Bevacizumab + Efgartigimod / hyaluronidase sc Moderate
Other interactions of Sorafenib
Frequently asked questions
Can I take Bevacizumab with Sorafenib?
MediHelp rates the interaction as moderate. Bevacizumab and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining bevacizumab with sorafenib has been associated with a higher frequency and severity of hand-foot skin reaction and also with additive hypertension and bleeding risk. This can limit tolerability and force dose reductions or interruption of therapy.
How serious is the interaction between Bevacizumab and Sorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Examine hands and feet regularly and monitor blood pressure at each visit. Reduce or hold sorafenib for significant skin toxicity and treat hypertension promptly.
What other medicines interact with Bevacizumab?
MediHelp also lists interactions of Bevacizumab with, for example, Sunitinib, Daunorubicin, Dengue vaccine. The full list is on the Bevacizumab page.
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