Drug interactions
Bexagliflozin + Tolbutamide
Severity: Moderate
Bexagliflozin and Tolbutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
SGLT2 inhibitors lower glucose independently of insulin, and adding one to a sulfonylurea increases the risk of hypoglycemia. The risk is greatest in patients with good baseline control or reduced renal function.
What this interaction means in plain words
Bexagliflozin and Tolbutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bexagliflozin belongs to Endocrine; Tolbutamide belongs to Endocrine.
Why it happens
Additive glucose lowering from insulin secretion (sulfonylurea) and urinary glucose excretion (SGLT2 inhibition).
What to do
Consider reducing the tolbutamide dose when bexagliflozin is started. Monitor blood glucose and counsel the patient on hypoglycemia symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Other interactions of Bexagliflozin
- Bexagliflozin + Carbamazepine Moderate
- Bexagliflozin + Chlorpropamide Moderate
- Bexagliflozin + Glibenclamide Moderate
- Bexagliflozin + Gliclazide Moderate
- Bexagliflozin + Glimepiride Moderate
- Bexagliflozin + Glimepiride-pioglitazone Moderate
Frequently asked questions
Can I take Bexagliflozin with Tolbutamide?
MediHelp rates the interaction as moderate. Bexagliflozin and Tolbutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. SGLT2 inhibitors lower glucose independently of insulin, and adding one to a sulfonylurea increases the risk of hypoglycemia. The risk is greatest in patients with good baseline control or reduced renal function.
How serious is the interaction between Bexagliflozin and Tolbutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the tolbutamide dose when bexagliflozin is started. Monitor blood glucose and counsel the patient on hypoglycemia symptoms.
What other medicines interact with Tolbutamide?
MediHelp also lists interactions of Tolbutamide with, for example, Glyburide-metformin, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolbutamide page.
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