Drug interactions
Bexarotene + Carbamazepine
Severity: Moderate
Bexarotene and Carbamazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bexarotene is metabolized by CYP3A4, and carbamazepine induction may lower bexarotene exposure and reduce its efficacy in cutaneous T-cell lymphoma.
What this interaction means in plain words
Bexarotene and Carbamazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bexarotene belongs to Oncology; Carbamazepine belongs to Central Nervous System.
Why it happens
Carbamazepine induces CYP3A4 metabolism of bexarotene.
What to do
Monitor disease response and consider a non-inducing antiseizure drug. Bexarotene dose adjustment may be needed if the combination is unavoidable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Other interactions of Bexarotene
- Bexarotene + Gemfibrozil Major
- Bexarotene + Lorlatinib Major
- Alogliptin-pioglitazone + Bexarotene Moderate
- Amobarbital + Bexarotene Moderate
- Aprepitant + Bexarotene Moderate
- Axitinib + Bexarotene Moderate
Frequently asked questions
Can I take Bexarotene with Carbamazepine?
MediHelp rates the interaction as moderate. Bexarotene and Carbamazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bexarotene is metabolized by CYP3A4, and carbamazepine induction may lower bexarotene exposure and reduce its efficacy in cutaneous T-cell lymphoma.
How serious is the interaction between Bexarotene and Carbamazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor disease response and consider a non-inducing antiseizure drug. Bexarotene dose adjustment may be needed if the combination is unavoidable.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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