Drug interactions
Bexarotene + Fluvoxamine
Severity: Minor
Bexarotene and Fluvoxamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bexarotene is metabolized in part by CYP3A4, and fluvoxamine is a weak inhibitor of this enzyme. Bexarotene exposure may increase slightly, though the clinical significance is probably small.
What this interaction means in plain words
Bexarotene and Fluvoxamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bexarotene belongs to Oncology; Fluvoxamine belongs to Central Nervous System.
Why it happens
Weak CYP3A4 inhibition by fluvoxamine may reduce bexarotene clearance.
What to do
No dose adjustment is generally required; monitor for bexarotene adverse effects such as hypertriglyceridemia and hypothyroidism as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Bexarotene
- Bexarotene + Gemfibrozil Major
- Bexarotene + Lorlatinib Major
- Alogliptin-pioglitazone + Bexarotene Moderate
- Amobarbital + Bexarotene Moderate
- Aprepitant + Bexarotene Moderate
- Axitinib + Bexarotene Moderate
Frequently asked questions
Can I take Bexarotene with Fluvoxamine?
MediHelp rates the interaction as minor. Bexarotene and Fluvoxamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bexarotene is metabolized in part by CYP3A4, and fluvoxamine is a weak inhibitor of this enzyme. Bexarotene exposure may increase slightly, though the clinical significance is probably small.
How serious is the interaction between Bexarotene and Fluvoxamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally required; monitor for bexarotene adverse effects such as hypertriglyceridemia and hypothyroidism as usual.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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