Drug interactions
Bexarotene + Insulin glargine
Severity: Minor
Bexarotene and Insulin glargine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bexarotene, a retinoid X receptor agonist, has been reported to improve insulin sensitivity and may increase the glucose-lowering effect of insulin, raising hypoglycemia risk.
What this interaction means in plain words
Bexarotene and Insulin glargine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bexarotene belongs to Oncology; Insulin glargine belongs to Endocrine.
Why it happens
RXR activation may enhance insulin sensitivity, adding to insulin's effect.
What to do
Monitor glucose when starting bexarotene and reduce the insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Insulin glargine
Other interactions of Bexarotene
- Bexarotene + Gemfibrozil Major
- Bexarotene + Lorlatinib Major
- Alogliptin-pioglitazone + Bexarotene Moderate
- Amobarbital + Bexarotene Moderate
- Aprepitant + Bexarotene Moderate
- Axitinib + Bexarotene Moderate
Frequently asked questions
Can I take Bexarotene with Insulin glargine?
MediHelp rates the interaction as minor. Bexarotene and Insulin glargine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bexarotene, a retinoid X receptor agonist, has been reported to improve insulin sensitivity and may increase the glucose-lowering effect of insulin, raising hypoglycemia risk.
How serious is the interaction between Bexarotene and Insulin glargine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose when starting bexarotene and reduce the insulin dose if hypoglycemia occurs.
What other medicines interact with Insulin glargine?
MediHelp also lists interactions of Insulin glargine with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin glargine page.
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