Drug interactions
Bexarotene + Rosiglitazone
Severity: Moderate
Bexarotene and Rosiglitazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bexarotene may enhance the glucose-lowering effect of insulin-sensitizing agents such as rosiglitazone, and hypoglycemia is a theoretical concern. Bexarotene alone is not known to cause hypoglycemia, so the risk is predicted rather than well documented.
What this interaction means in plain words
Bexarotene and Rosiglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bexarotene belongs to Oncology; Rosiglitazone belongs to Endocrine.
Why it happens
Additive pharmacodynamic insulin-sensitizing effect predicted from the mechanism of action; bexarotene also may induce CYP3A4 but rosiglitazone is mainly CYP2C8 metabolized.
What to do
Monitor blood glucose when bexarotene is started or stopped in patients taking rosiglitazone. Reduce the rosiglitazone dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rosiglitazone
- Insulin aspart protamine / insulin aspart + Rosiglitazone Major
- Insulin aspart-insulin aspart protamine + Rosiglitazone Major
- Insulin aspart + Rosiglitazone Major
- Insulin degludec / insulin aspart + Rosiglitazone Major
- Insulin degludec-insulin aspart + Rosiglitazone Major
- Insulin degludec-liraglutide + Rosiglitazone Major
Other interactions of Bexarotene
- Bexarotene + Gemfibrozil Major
- Bexarotene + Lorlatinib Major
- Alogliptin-pioglitazone + Bexarotene Moderate
- Amobarbital + Bexarotene Moderate
- Aprepitant + Bexarotene Moderate
- Axitinib + Bexarotene Moderate
Frequently asked questions
Can I take Bexarotene with Rosiglitazone?
MediHelp rates the interaction as moderate. Bexarotene and Rosiglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bexarotene may enhance the glucose-lowering effect of insulin-sensitizing agents such as rosiglitazone, and hypoglycemia is a theoretical concern. Bexarotene alone is not known to cause hypoglycemia, so the risk is predicted rather than well documented.
How serious is the interaction between Bexarotene and Rosiglitazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when bexarotene is started or stopped in patients taking rosiglitazone. Reduce the rosiglitazone dose if hypoglycemia occurs.
What other medicines interact with Rosiglitazone?
MediHelp also lists interactions of Rosiglitazone with, for example, Insulin aspart protamine / insulin aspart, Insulin aspart-insulin aspart protamine, Insulin aspart. The full list is on the Rosiglitazone page.
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