Drug interactions
Bicalutamide + Cobimetinib
Severity: Minor
Bicalutamide and Cobimetinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bicalutamide may weakly inhibit CYP3A4 and modestly raise cobimetinib levels. The effect is likely small, though cobimetinib toxicities include hemorrhage, rash and cardiomyopathy.
What this interaction means in plain words
Bicalutamide and Cobimetinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bicalutamide belongs to Endocrine; Cobimetinib belongs to Oncology.
Why it happens
Weak possible CYP3A4 inhibition by bicalutamide reduces cobimetinib metabolism.
What to do
No empirical dose change is needed; monitor for cobimetinib adverse effects including rash, bleeding and decreased ejection fraction.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bicalutamide
- Bicalutamide + Lomitapide Major
- Aminolevulinic acid + Bicalutamide Moderate
- Bicalutamide + Eliglustat Moderate
- Bicalutamide + Flibanserin Moderate
- Bicalutamide + Ivosidenib Moderate
- Bicalutamide + Lonafarnib Moderate
Other interactions of Cobimetinib
- Cobimetinib + Efavirenz Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Amobarbital + Cobimetinib Major
- Apalutamide + Cobimetinib Major
- Aprepitant + Cobimetinib Major
- Bosentan + Cobimetinib Major
Frequently asked questions
Can I take Bicalutamide with Cobimetinib?
MediHelp rates the interaction as minor. Bicalutamide and Cobimetinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bicalutamide may weakly inhibit CYP3A4 and modestly raise cobimetinib levels. The effect is likely small, though cobimetinib toxicities include hemorrhage, rash and cardiomyopathy.
How serious is the interaction between Bicalutamide and Cobimetinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed; monitor for cobimetinib adverse effects including rash, bleeding and decreased ejection fraction.
What other medicines interact with Bicalutamide?
MediHelp also lists interactions of Bicalutamide with, for example, Lomitapide, Aminolevulinic acid, Eliglustat. The full list is on the Bicalutamide page.
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