Drug interactions
Bicalutamide + Entrectinib
Severity: Minor
Bicalutamide and Entrectinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bicalutamide may weakly inhibit CYP3A4 and slightly raise entrectinib exposure. Entrectinib can cause QT prolongation, heart failure and CNS effects, so increased exposure could matter.
What this interaction means in plain words
Bicalutamide and Entrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bicalutamide belongs to Endocrine; Entrectinib belongs to Oncology.
Why it happens
Weak possible CYP3A4 inhibition by bicalutamide reduces entrectinib metabolism.
What to do
No empirical dose reduction is needed; monitor ECG, and watch for cognitive effects and heart failure.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bicalutamide
- Bicalutamide + Lomitapide Major
- Aminolevulinic acid + Bicalutamide Moderate
- Bicalutamide + Eliglustat Moderate
- Bicalutamide + Flibanserin Moderate
- Bicalutamide + Ivosidenib Moderate
- Bicalutamide + Lonafarnib Moderate
Other interactions of Entrectinib
Frequently asked questions
Can I take Bicalutamide with Entrectinib?
MediHelp rates the interaction as minor. Bicalutamide and Entrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bicalutamide may weakly inhibit CYP3A4 and slightly raise entrectinib exposure. Entrectinib can cause QT prolongation, heart failure and CNS effects, so increased exposure could matter.
How serious is the interaction between Bicalutamide and Entrectinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose reduction is needed; monitor ECG, and watch for cognitive effects and heart failure.
What other medicines interact with Bicalutamide?
MediHelp also lists interactions of Bicalutamide with, for example, Lomitapide, Aminolevulinic acid, Eliglustat. The full list is on the Bicalutamide page.
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