Drug interactions
Bicalutamide + Irinotecan
Severity: Minor
Bicalutamide and Irinotecan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Irinotecan is metabolized by CYP3A4 to inactive products and activated by carboxylesterases. Bicalutamide's weak CYP3A4 inhibition could modestly change exposure to irinotecan and its active metabolite, but the effect is likely small.
What this interaction means in plain words
Bicalutamide and Irinotecan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bicalutamide belongs to Endocrine; Irinotecan belongs to Oncology.
Why it happens
Weak CYP3A4 inhibition by bicalutamide may alter irinotecan metabolism.
What to do
Monitor for diarrhea and neutropenia as part of routine irinotecan care; no dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bicalutamide
- Bicalutamide + Lomitapide Major
- Aminolevulinic acid + Bicalutamide Moderate
- Bicalutamide + Eliglustat Moderate
- Bicalutamide + Flibanserin Moderate
- Bicalutamide + Ivosidenib Moderate
- Bicalutamide + Lonafarnib Moderate
Other interactions of Irinotecan
- Clozapine + Irinotecan Contraindicated
- Irinotecan + Sacituzumab govitecan Contraindicated
- Adenovirus types 4 and 7 live + Irinotecan Major
- Apalutamide + Irinotecan Major
- Atazanavir + Irinotecan Major
- Carbamazepine + Irinotecan Major
Frequently asked questions
Can I take Bicalutamide with Irinotecan?
MediHelp rates the interaction as minor. Bicalutamide and Irinotecan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Irinotecan is metabolized by CYP3A4 to inactive products and activated by carboxylesterases. Bicalutamide's weak CYP3A4 inhibition could modestly change exposure to irinotecan and its active metabolite, but the effect is likely small.
How serious is the interaction between Bicalutamide and Irinotecan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for diarrhea and neutropenia as part of routine irinotecan care; no dose change is needed.
What other medicines interact with Bicalutamide?
MediHelp also lists interactions of Bicalutamide with, for example, Lomitapide, Aminolevulinic acid, Eliglustat. The full list is on the Bicalutamide page.
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