Drug interactions
Bicalutamide + Mavacamten
Severity: Moderate
Bicalutamide and Mavacamten: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mavacamten is metabolized by CYP2C19 and CYP3A4, and higher exposure can reduce ejection fraction and cause heart failure. Bicalutamide is a weak CYP3A4 inhibitor, so the effect is probably limited but the drug has a narrow margin.
What this interaction means in plain words
Bicalutamide and Mavacamten can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bicalutamide belongs to Endocrine; Mavacamten belongs to Cardiovascular.
Why it happens
Possible weak inhibition of CYP3A4-mediated mavacamten metabolism by bicalutamide.
What to do
Monitor LVEF by echocardiography according to mavacamten labeling and reassess dose if ejection fraction falls or heart failure symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bicalutamide
- Bicalutamide + Lomitapide Major
- Aminolevulinic acid + Bicalutamide Moderate
- Bicalutamide + Eliglustat Moderate
- Bicalutamide + Flibanserin Moderate
- Bicalutamide + Ivosidenib Moderate
- Bicalutamide + Lonafarnib Moderate
Other interactions of Mavacamten
- Apalutamide + Mavacamten Contraindicated
- Carbamazepine + Mavacamten Contraindicated
- Clarithromycin + Mavacamten Contraindicated
- Dexlansoprazole + Mavacamten Contraindicated
- Efavirenz + Mavacamten Contraindicated
- Enzalutamide + Mavacamten Contraindicated
Frequently asked questions
Can I take Bicalutamide with Mavacamten?
MediHelp rates the interaction as moderate. Bicalutamide and Mavacamten can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mavacamten is metabolized by CYP2C19 and CYP3A4, and higher exposure can reduce ejection fraction and cause heart failure. Bicalutamide is a weak CYP3A4 inhibitor, so the effect is probably limited but the drug has a narrow margin.
How serious is the interaction between Bicalutamide and Mavacamten?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor LVEF by echocardiography according to mavacamten labeling and reassess dose if ejection fraction falls or heart failure symptoms appear.
What other medicines interact with Bicalutamide?
MediHelp also lists interactions of Bicalutamide with, for example, Lomitapide, Aminolevulinic acid, Eliglustat. The full list is on the Bicalutamide page.
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