Drug interactions
Bicalutamide + Lumateperone
Severity: Minor
Bicalutamide and Lumateperone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumateperone is metabolized by CYP3A4 and exposure increases with inhibitors, raising sedation and orthostasis risk. Bicalutamide is a weak inhibitor, so a clinically important rise is unlikely.
What this interaction means in plain words
Bicalutamide and Lumateperone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bicalutamide belongs to Endocrine; Lumateperone belongs to Central Nervous System.
Why it happens
Possible weak inhibition of CYP3A4-mediated lumateperone metabolism by bicalutamide.
What to do
Monitor for sedation and orthostatic hypotension; reduce lumateperone to 21 mg daily only if a meaningful inhibitory effect is suspected.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bicalutamide
- Bicalutamide + Lomitapide Major
- Aminolevulinic acid + Bicalutamide Moderate
- Bicalutamide + Eliglustat Moderate
- Bicalutamide + Flibanserin Moderate
- Bicalutamide + Ivosidenib Moderate
- Bicalutamide + Lonafarnib Moderate
Other interactions of Lumateperone
Frequently asked questions
Can I take Bicalutamide with Lumateperone?
MediHelp rates the interaction as minor. Bicalutamide and Lumateperone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lumateperone is metabolized by CYP3A4 and exposure increases with inhibitors, raising sedation and orthostasis risk. Bicalutamide is a weak inhibitor, so a clinically important rise is unlikely.
How serious is the interaction between Bicalutamide and Lumateperone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and orthostatic hypotension; reduce lumateperone to 21 mg daily only if a meaningful inhibitory effect is suspected.
What other medicines interact with Bicalutamide?
MediHelp also lists interactions of Bicalutamide with, for example, Lomitapide, Aminolevulinic acid, Eliglustat. The full list is on the Bicalutamide page.
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