Drug interactions
Bicalutamide + Norgestrel
Severity: Minor
Bicalutamide and Norgestrel: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Norgestrel is metabolized in part by CYP3A4, but bicalutamide has weak inhibitory activity, so a meaningful change in progestin exposure is unlikely. The pairing is rarely relevant clinically.
What this interaction means in plain words
Bicalutamide and Norgestrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bicalutamide belongs to Endocrine; Norgestrel belongs to Endocrine.
Why it happens
Weak CYP3A4 inhibition may slightly slow norgestrel metabolism.
What to do
No action needed beyond routine monitoring for progestogenic adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bicalutamide
- Bicalutamide + Lomitapide Major
- Aminolevulinic acid + Bicalutamide Moderate
- Bicalutamide + Eliglustat Moderate
- Bicalutamide + Flibanserin Moderate
- Bicalutamide + Ivosidenib Moderate
- Bicalutamide + Lonafarnib Moderate
Other interactions of Norgestrel
- Amobarbital + Norgestrel Major
- Apalutamide + Norgestrel Major
- Bosentan + Norgestrel Major
- Carbamazepine + Norgestrel Major
- Efavirenz + Norgestrel Major
- Enzalutamide + Norgestrel Major
Frequently asked questions
Can I take Bicalutamide with Norgestrel?
MediHelp rates the interaction as minor. Bicalutamide and Norgestrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Norgestrel is metabolized in part by CYP3A4, but bicalutamide has weak inhibitory activity, so a meaningful change in progestin exposure is unlikely. The pairing is rarely relevant clinically.
How serious is the interaction between Bicalutamide and Norgestrel?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action needed beyond routine monitoring for progestogenic adverse effects.
What other medicines interact with Bicalutamide?
MediHelp also lists interactions of Bicalutamide with, for example, Lomitapide, Aminolevulinic acid, Eliglustat. The full list is on the Bicalutamide page.
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