Drug interactions
Bicalutamide + Palovarotene
Severity: Moderate
Bicalutamide and Palovarotene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Palovarotene is a CYP3A substrate and inhibitors increase exposure, raising retinoid toxicity such as mucocutaneous effects and premature growth plate closure. Bicalutamide is a weak CYP3A4 inhibitor, so the effect is probably modest.
What this interaction means in plain words
Bicalutamide and Palovarotene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bicalutamide belongs to Endocrine; Palovarotene belongs to Miscellaneous.
Why it happens
Possible weak inhibition of CYP3A-mediated palovarotene metabolism by bicalutamide.
What to do
Monitor for retinoid adverse effects; reduce palovarotene dose per labeling if a clinically relevant CYP3A inhibitory effect is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bicalutamide
- Bicalutamide + Lomitapide Major
- Aminolevulinic acid + Bicalutamide Moderate
- Bicalutamide + Eliglustat Moderate
- Bicalutamide + Flibanserin Moderate
- Bicalutamide + Ivosidenib Moderate
- Bicalutamide + Lonafarnib Moderate
Other interactions of Palovarotene
- Acitretin + Palovarotene Contraindicated
- Isotretinoin + Palovarotene Contraindicated
- Amiodarone + Palovarotene Major
- Amobarbital + Palovarotene Major
- Apalutamide + Palovarotene Major
- Aprepitant + Palovarotene Major
Frequently asked questions
Can I take Bicalutamide with Palovarotene?
MediHelp rates the interaction as moderate. Bicalutamide and Palovarotene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Palovarotene is a CYP3A substrate and inhibitors increase exposure, raising retinoid toxicity such as mucocutaneous effects and premature growth plate closure. Bicalutamide is a weak CYP3A4 inhibitor, so the effect is probably modest.
How serious is the interaction between Bicalutamide and Palovarotene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for retinoid adverse effects; reduce palovarotene dose per labeling if a clinically relevant CYP3A inhibitory effect is suspected.
What other medicines interact with Bicalutamide?
MediHelp also lists interactions of Bicalutamide with, for example, Lomitapide, Aminolevulinic acid, Eliglustat. The full list is on the Bicalutamide page.
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