Drug interactions
Bicalutamide + Siponimod
Severity: Minor
Bicalutamide and Siponimod: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bicalutamide is a weak CYP3A4 inhibitor in vitro and has little effect in practice on exposure to most CYP3A4 substrates. Siponimod is cleared mainly by CYP2C9 with a smaller CYP3A4 contribution, so a clinically meaningful rise in siponimod levels is not expected.
What this interaction means in plain words
Bicalutamide and Siponimod have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bicalutamide belongs to Endocrine; Siponimod belongs to Central Nervous System.
Why it happens
Weak CYP3A4 inhibition by bicalutamide may slightly reduce the minor CYP3A4 clearance pathway of siponimod.
What to do
No dose change is needed; be aware of the interaction if the patient also takes a CYP2C9 inhibitor.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Siponimod
- Cladribine + Siponimod Contraindicated
- Fingolimod + Siponimod Contraindicated
- Fluconazole + Siponimod Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Siponimod Contraindicated
- Ponesimod + Siponimod Contraindicated
- Siponimod + Thioridazine Contraindicated
Other interactions of Bicalutamide
- Bicalutamide + Lomitapide Major
- Aminolevulinic acid + Bicalutamide Moderate
- Bicalutamide + Eliglustat Moderate
- Bicalutamide + Flibanserin Moderate
- Bicalutamide + Ivosidenib Moderate
- Bicalutamide + Lonafarnib Moderate
Frequently asked questions
Can I take Bicalutamide with Siponimod?
MediHelp rates the interaction as minor. Bicalutamide and Siponimod have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bicalutamide is a weak CYP3A4 inhibitor in vitro and has little effect in practice on exposure to most CYP3A4 substrates. Siponimod is cleared mainly by CYP2C9 with a smaller CYP3A4 contribution, so a clinically meaningful rise in siponimod levels is not expected.
How serious is the interaction between Bicalutamide and Siponimod?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; be aware of the interaction if the patient also takes a CYP2C9 inhibitor.
What other medicines interact with Siponimod?
MediHelp also lists interactions of Siponimod with, for example, Cladribine, Fingolimod, Fluconazole. The full list is on the Siponimod page.
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