Drug interactions
Bicalutamide + Suvorexant
Severity: Minor
Bicalutamide and Suvorexant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Suvorexant is cleared mainly by CYP3A4 and inhibitors raise exposure, increasing next-day somnolence. Bicalutamide is a weak inhibitor, so any change is likely small.
What this interaction means in plain words
Bicalutamide and Suvorexant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bicalutamide belongs to Endocrine; Suvorexant belongs to Central Nervous System.
Why it happens
Possible weak inhibition of CYP3A4-mediated suvorexant metabolism by bicalutamide.
What to do
No routine adjustment is needed; monitor for daytime drowsiness and consider a 5 mg starting dose if sedation occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bicalutamide
- Bicalutamide + Lomitapide Major
- Aminolevulinic acid + Bicalutamide Moderate
- Bicalutamide + Eliglustat Moderate
- Bicalutamide + Flibanserin Moderate
- Bicalutamide + Ivosidenib Moderate
- Bicalutamide + Lonafarnib Moderate
Other interactions of Suvorexant
Frequently asked questions
Can I take Bicalutamide with Suvorexant?
MediHelp rates the interaction as minor. Bicalutamide and Suvorexant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Suvorexant is cleared mainly by CYP3A4 and inhibitors raise exposure, increasing next-day somnolence. Bicalutamide is a weak inhibitor, so any change is likely small.
How serious is the interaction between Bicalutamide and Suvorexant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for daytime drowsiness and consider a 5 mg starting dose if sedation occurs.
What other medicines interact with Bicalutamide?
MediHelp also lists interactions of Bicalutamide with, for example, Lomitapide, Aminolevulinic acid, Eliglustat. The full list is on the Bicalutamide page.
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