Drug interactions
Bicalutamide + Trabectedin
Severity: Minor
Bicalutamide and Trabectedin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trabectedin is mainly metabolized by CYP3A4, and inhibitors can raise exposure and toxicity. Bicalutamide is only a weak inhibitor, so the risk is likely low, though trabectedin hepatotoxicity warrants awareness.
What this interaction means in plain words
Bicalutamide and Trabectedin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bicalutamide belongs to Endocrine; Trabectedin belongs to Oncology.
Why it happens
Weak CYP3A4 inhibition may slightly reduce trabectedin clearance.
What to do
No dose change; monitor liver enzymes and CPK as routinely required during trabectedin treatment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bicalutamide
- Bicalutamide + Lomitapide Major
- Aminolevulinic acid + Bicalutamide Moderate
- Bicalutamide + Eliglustat Moderate
- Bicalutamide + Flibanserin Moderate
- Bicalutamide + Ivosidenib Moderate
- Bicalutamide + Lonafarnib Moderate
Other interactions of Trabectedin
Frequently asked questions
Can I take Bicalutamide with Trabectedin?
MediHelp rates the interaction as minor. Bicalutamide and Trabectedin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Trabectedin is mainly metabolized by CYP3A4, and inhibitors can raise exposure and toxicity. Bicalutamide is only a weak inhibitor, so the risk is likely low, though trabectedin hepatotoxicity warrants awareness.
How serious is the interaction between Bicalutamide and Trabectedin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change; monitor liver enzymes and CPK as routinely required during trabectedin treatment.
What other medicines interact with Bicalutamide?
MediHelp also lists interactions of Bicalutamide with, for example, Lomitapide, Aminolevulinic acid, Eliglustat. The full list is on the Bicalutamide page.
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