Drug interactions
Bismuth subsalicylate + Eluxadoline
Severity: Moderate
Bismuth subsalicylate and Eluxadoline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eluxadoline can cause constipation and, rarely, serious complications such as pancreatitis or sphincter of Oddi spasm. Bismuth subsalicylate has constipating effects that may add to this risk, and the combination is of limited benefit.
What this interaction means in plain words
Bismuth subsalicylate and Eluxadoline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bismuth subsalicylate belongs to Gastrointestinal Tract; Eluxadoline belongs to Gastrointestinal Tract.
Why it happens
Additive antimotility and constipating effects (mu-opioid agonism with eluxadoline and bismuth's antidiarrheal action).
What to do
Avoid routine concomitant use of bismuth subsalicylate. If constipation develops, stop the antidiarrheal and reassess eluxadoline.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bismuth subsalicylate
- Bismuth subsalicylate + Dichlorphenamide Major
- Bismuth subsalicylate + Warfarin Major
- Acetylsalicylic acid + Bismuth subsalicylate Moderate
- Amlodipine-benazepril + Bismuth subsalicylate Moderate
- Aspirin / citric acid / sodium bicarbonate + Bismuth subsalicylate Moderate
- Aspirin rectal + Bismuth subsalicylate Moderate
Other interactions of Eluxadoline
Frequently asked questions
Can I take Bismuth subsalicylate with Eluxadoline?
MediHelp rates the interaction as moderate. Bismuth subsalicylate and Eluxadoline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eluxadoline can cause constipation and, rarely, serious complications such as pancreatitis or sphincter of Oddi spasm. Bismuth subsalicylate has constipating effects that may add to this risk, and the combination is of limited benefit.
How serious is the interaction between Bismuth subsalicylate and Eluxadoline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine concomitant use of bismuth subsalicylate. If constipation develops, stop the antidiarrheal and reassess eluxadoline.
What other medicines interact with Bismuth subsalicylate?
MediHelp also lists interactions of Bismuth subsalicylate with, for example, Dichlorphenamide, Warfarin, Acetylsalicylic acid. The full list is on the Bismuth subsalicylate page.
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