Drug interactions
Bismuth subsalicylate + Omadacycline
Severity: Moderate
Bismuth subsalicylate and Omadacycline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bismuth in bismuth subsalicylate can chelate oral omadacycline and reduce its absorption. This may lower antibiotic exposure and efficacy.
What this interaction means in plain words
Bismuth subsalicylate and Omadacycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bismuth subsalicylate belongs to Gastrointestinal Tract; Omadacycline belongs to Anti Bacterial.
Why it happens
Chelation of omadacycline by polyvalent bismuth cations in the GI tract reduces absorption.
What to do
Avoid taking omadacycline within several hours of bismuth subsalicylate; labeling advises waiting at least 4 hours after omadacycline before polyvalent-cation products. Monitor clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bismuth subsalicylate
- Bismuth subsalicylate + Dichlorphenamide Major
- Bismuth subsalicylate + Warfarin Major
- Acetylsalicylic acid + Bismuth subsalicylate Moderate
- Amlodipine-benazepril + Bismuth subsalicylate Moderate
- Aspirin / citric acid / sodium bicarbonate + Bismuth subsalicylate Moderate
- Aspirin rectal + Bismuth subsalicylate Moderate
Other interactions of Omadacycline
- Acitretin + Omadacycline Contraindicated
- Isotretinoin + Omadacycline Major
- Omadacycline + Tretinoin Major
- Aluminum hydroxide + Omadacycline Moderate
- Amoxicillin-clavulanic acid + Omadacycline Moderate
- Amoxicillin + Omadacycline Moderate
Frequently asked questions
Can I take Bismuth subsalicylate with Omadacycline?
MediHelp rates the interaction as moderate. Bismuth subsalicylate and Omadacycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bismuth in bismuth subsalicylate can chelate oral omadacycline and reduce its absorption. This may lower antibiotic exposure and efficacy.
How serious is the interaction between Bismuth subsalicylate and Omadacycline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid taking omadacycline within several hours of bismuth subsalicylate; labeling advises waiting at least 4 hours after omadacycline before polyvalent-cation products. Monitor clinical response.
What other medicines interact with Bismuth subsalicylate?
MediHelp also lists interactions of Bismuth subsalicylate with, for example, Dichlorphenamide, Warfarin, Acetylsalicylic acid. The full list is on the Bismuth subsalicylate page.
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