Drug interactions
Bisoprolol + Digoxin
Severity: Moderate
Bisoprolol and Digoxin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both slow AV nodal conduction, so together they can cause bradycardia and heart block. The combination is commonly used in atrial fibrillation or heart failure but needs surveillance.
What this interaction means in plain words
Bisoprolol and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bisoprolol belongs to Cardiovascular; Digoxin belongs to Cardiovascular.
Why it happens
Additive depression of AV nodal conduction through beta-blockade and digoxin vagotonic effect.
What to do
Monitor heart rate, ECG and symptoms of bradycardia or dizziness, and check digoxin levels if toxicity is suspected. Adjust the dose of either agent if significant bradycardia or AV block develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bisoprolol
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Bisoprolol with Digoxin?
MediHelp rates the interaction as moderate. Bisoprolol and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both slow AV nodal conduction, so together they can cause bradycardia and heart block. The combination is commonly used in atrial fibrillation or heart failure but needs surveillance.
How serious is the interaction between Bisoprolol and Digoxin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, ECG and symptoms of bradycardia or dizziness, and check digoxin levels if toxicity is suspected. Adjust the dose of either agent if significant bradycardia or AV block develops.
What other medicines interact with Bisoprolol?
MediHelp also lists interactions of Bisoprolol with, for example, Aldesleukin, Amifostine, Amiodarone. The full list is on the Bisoprolol page.
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