Drug interactions
Bisoprolol + Dihydroergotamine
Severity: Moderate
Bisoprolol and Dihydroergotamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dihydroergotamine causes vasoconstriction, and beta-blockers may leave peripheral vasoconstriction unopposed, adding to ischemic effects. Cold extremities and, rarely, severe peripheral ischemia can occur.
What this interaction means in plain words
Bisoprolol and Dihydroergotamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bisoprolol belongs to Cardiovascular; Dihydroergotamine belongs to Central Nervous System.
Why it happens
Additive peripheral vasoconstriction from ergot alpha-agonism and beta-2 blockade.
What to do
Monitor for cold extremities, numbness or claudication. Stop dihydroergotamine if signs of ischemia appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bisoprolol
Other interactions of Dihydroergotamine
- Almotriptan + Dihydroergotamine Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
- Dihydroergotamine + Dopamine Contraindicated
- Dihydroergotamine + Dronedarone Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Dihydroergotamine + Eletriptan Contraindicated
Frequently asked questions
Can I take Bisoprolol with Dihydroergotamine?
MediHelp rates the interaction as moderate. Bisoprolol and Dihydroergotamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dihydroergotamine causes vasoconstriction, and beta-blockers may leave peripheral vasoconstriction unopposed, adding to ischemic effects. Cold extremities and, rarely, severe peripheral ischemia can occur.
How serious is the interaction between Bisoprolol and Dihydroergotamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for cold extremities, numbness or claudication. Stop dihydroergotamine if signs of ischemia appear.
What other medicines interact with Bisoprolol?
MediHelp also lists interactions of Bisoprolol with, for example, Aldesleukin, Amifostine, Amiodarone. The full list is on the Bisoprolol page.
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