Drug interactions
Bisoprolol + Indacaterol
Severity: Moderate
Bisoprolol and Indacaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bisoprolol can blunt the bronchodilator effect of indacaterol and may provoke bronchospasm, particularly at higher doses where selectivity is lost. In patients with a firm cardiac indication it is often still used.
What this interaction means in plain words
Bisoprolol and Indacaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bisoprolol belongs to Cardiovascular; Indacaterol belongs to Respiratory.
Why it happens
Pharmacodynamic antagonism at beta-adrenergic receptors; selectivity is dose dependent.
What to do
Use the lowest effective bisoprolol dose when needed in COPD or asthma and monitor respiratory symptoms and lung function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol
Other interactions of Bisoprolol
Frequently asked questions
Can I take Bisoprolol with Indacaterol?
MediHelp rates the interaction as moderate. Bisoprolol and Indacaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bisoprolol can blunt the bronchodilator effect of indacaterol and may provoke bronchospasm, particularly at higher doses where selectivity is lost. In patients with a firm cardiac indication it is often still used.
How serious is the interaction between Bisoprolol and Indacaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective bisoprolol dose when needed in COPD or asthma and monitor respiratory symptoms and lung function.
What other medicines interact with Indacaterol?
MediHelp also lists interactions of Indacaterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Indacaterol page.
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