Drug interactions
Bisoprolol + Sevoflurane
Severity: Moderate
Bisoprolol and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sevoflurane lowers vascular resistance and depresses myocardial contractility, and bisoprolol blunts compensatory responses. Hypotension and bradycardia may be more pronounced during anesthesia.
What this interaction means in plain words
Bisoprolol and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bisoprolol belongs to Cardiovascular; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic cardiovascular depression from volatile anesthetic effects and beta-1 blockade.
What to do
Inform the anesthesia team of beta-blocker use and monitor blood pressure and heart rate throughout. Usually continue chronic beta-blockers perioperatively and treat hypotension as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Bisoprolol and Sevoflurane, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Bisoprolol
Other interactions of Sevoflurane
Frequently asked questions
Can I take Bisoprolol with Sevoflurane?
MediHelp rates the interaction as moderate. Bisoprolol and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sevoflurane lowers vascular resistance and depresses myocardial contractility, and bisoprolol blunts compensatory responses. Hypotension and bradycardia may be more pronounced during anesthesia.
How serious is the interaction between Bisoprolol and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team of beta-blocker use and monitor blood pressure and heart rate throughout. Usually continue chronic beta-blockers perioperatively and treat hypotension as needed.
What other medicines interact with Bisoprolol?
MediHelp also lists interactions of Bisoprolol with, for example, Aldesleukin, Amifostine, Amiodarone. The full list is on the Bisoprolol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
