Drug interactions
Bisoprolol + Sotalol
Severity: Major
Bisoprolol and Sotalol: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are beta-blockers and sotalol additionally prolongs the QT interval, so combining them duplicates therapy. Bradycardia, hypotension, AV block and torsades de pointes risk are increased.
What this interaction means in plain words
Bisoprolol and Sotalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bisoprolol belongs to Cardiovascular; Sotalol belongs to Cardiovascular.
Why it happens
Additive beta-adrenergic blockade with added potassium-channel blockade from sotalol.
What to do
Avoid combining; use one agent appropriate for the indication. If overlap occurs, stop one and monitor heart rate, blood pressure and QTc.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Bisoprolol and Sotalol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
Other interactions of Bisoprolol
Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Frequently asked questions
Can I take Bisoprolol with Sotalol?
MediHelp rates the interaction as major. Bisoprolol and Sotalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are beta-blockers and sotalol additionally prolongs the QT interval, so combining them duplicates therapy. Bradycardia, hypotension, AV block and torsades de pointes risk are increased.
How serious is the interaction between Bisoprolol and Sotalol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining; use one agent appropriate for the indication. If overlap occurs, stop one and monitor heart rate, blood pressure and QTc.
What other medicines interact with Bisoprolol?
MediHelp also lists interactions of Bisoprolol with, for example, Aldesleukin, Amifostine, Amiodarone. The full list is on the Bisoprolol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
