Drug interactions
Bivalirudin + Estradiol
Severity: Moderate
Bivalirudin and Estradiol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estrogens promote clotting and could theoretically reduce the net effect of bivalirudin, though bivalirudin is short-acting and used in procedural settings.
What this interaction means in plain words
Bivalirudin and Estradiol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Estradiol raises procoagulant factors, opposing direct thrombin inhibition in a pharmacodynamic manner.
What to do
Monitor ACT or coagulation parameters during bivalirudin use and for thrombosis in patients on estrogen.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Frequently asked questions
Can I take Bivalirudin with Estradiol?
MediHelp rates the interaction as moderate. Bivalirudin and Estradiol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Estrogens promote clotting and could theoretically reduce the net effect of bivalirudin, though bivalirudin is short-acting and used in procedural settings.
How serious is the interaction between Bivalirudin and Estradiol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ACT or coagulation parameters during bivalirudin use and for thrombosis in patients on estrogen.
What other medicines interact with Estradiol?
MediHelp also lists interactions of Estradiol with, for example, Anastrozole, Fezolinetant, Ospemifene. The full list is on the Estradiol page.
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