Drug interactions
Bivalirudin + Melatonin
Severity: Minor
Bivalirudin and Melatonin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Melatonin has been reported to have minor effects on coagulation and platelet function, so it could theoretically add to the bleeding risk of a direct thrombin inhibitor. The clinical evidence is weak and a meaningful effect is unlikely.
What this interaction means in plain words
Bivalirudin and Melatonin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible weak additive effect on hemostasis; the mechanism is not well established.
What to do
No routine change is needed; monitor aPTT or ACT as usual during bivalirudin therapy and watch for bleeding.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Melatonin
- Fluvoxamine + Melatonin Major
- Alfentanil + Melatonin Moderate
- Belladonna and opium + Melatonin Moderate
- Buprenorphine buccal + Melatonin Moderate
- Butabarbital + Melatonin Moderate
- Butalbital + Melatonin Moderate
Frequently asked questions
Can I take Bivalirudin with Melatonin?
MediHelp rates the interaction as minor. Bivalirudin and Melatonin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Melatonin has been reported to have minor effects on coagulation and platelet function, so it could theoretically add to the bleeding risk of a direct thrombin inhibitor. The clinical evidence is weak and a meaningful effect is unlikely.
How serious is the interaction between Bivalirudin and Melatonin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; monitor aPTT or ACT as usual during bivalirudin therapy and watch for bleeding.
What other medicines interact with Melatonin?
MediHelp also lists interactions of Melatonin with, for example, Fluvoxamine, Alfentanil, Belladonna and opium. The full list is on the Melatonin page.
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