Drug interactions
Bivalirudin + Vortioxetine
Severity: Moderate
Bivalirudin and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bivalirudin is a direct thrombin inhibitor used in procedures and carries a bleeding risk. Vortioxetine can impair platelet function, so bleeding may be somewhat increased.
What this interaction means in plain words
Bivalirudin and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hemostatic effects: direct thrombin inhibition plus serotonin-mediated platelet dysfunction.
What to do
Monitor for bleeding at access sites and elsewhere during and after bivalirudin infusion. Review the need for vortioxetine in patients with active bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Frequently asked questions
Can I take Bivalirudin with Vortioxetine?
MediHelp rates the interaction as moderate. Bivalirudin and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bivalirudin is a direct thrombin inhibitor used in procedures and carries a bleeding risk. Vortioxetine can impair platelet function, so bleeding may be somewhat increased.
How serious is the interaction between Bivalirudin and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding at access sites and elsewhere during and after bivalirudin infusion. Review the need for vortioxetine in patients with active bleeding.
What other medicines interact with Vortioxetine?
MediHelp also lists interactions of Vortioxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Vortioxetine page.
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