Drug interactions
Bleomycin + Olaparib
Severity: Moderate
Bleomycin and Olaparib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olaparib commonly causes cytopenias and bleomycin can add to marrow toxicity, although bleomycin is relatively marrow-sparing. Together they may prolong or worsen blood count suppression.
What this interaction means in plain words
Bleomycin and Olaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bleomycin belongs to Oncology; Olaparib belongs to Oncology.
Why it happens
Additive hematologic toxicity from DNA-damaging and PARP-inhibiting effects.
What to do
Monitor complete blood counts regularly and modify olaparib or other doses for significant cytopenias.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bleomycin
- Adenovirus types 4 and 7 live + Bleomycin Contraindicated
- Bleomycin + Brentuximab Contraindicated
- Bleomycin + Brentuximab vedotin Contraindicated
- Bleomycin + Dengue vaccine Major
- Bleomycin + Trastuzumab deruxtecan Major
- Bleomycin + Cholera vaccine Moderate
Other interactions of Olaparib
- Amiodarone + Olaparib Major
- Amobarbital + Olaparib Major
- Apalutamide + Olaparib Major
- Aprepitant + Olaparib Major
- Azathioprine + Olaparib Major
- Carbamazepine + Olaparib Major
Frequently asked questions
Can I take Bleomycin with Olaparib?
MediHelp rates the interaction as moderate. Bleomycin and Olaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olaparib commonly causes cytopenias and bleomycin can add to marrow toxicity, although bleomycin is relatively marrow-sparing. Together they may prolong or worsen blood count suppression.
How serious is the interaction between Bleomycin and Olaparib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts regularly and modify olaparib or other doses for significant cytopenias.
What other medicines interact with Bleomycin?
MediHelp also lists interactions of Bleomycin with, for example, Adenovirus types 4 and 7 live, Brentuximab, Brentuximab vedotin. The full list is on the Bleomycin page.
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