Drug interactions
Bleomycin + Tenofovir df
Severity: Moderate
Bleomycin and Tenofovir df: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bleomycin is renally eliminated and can be nephrotoxic, while tenofovir is also cleared by the kidney and can cause tubular injury. Reduced renal function may increase exposure to both drugs and worsen toxicity.
What this interaction means in plain words
Bleomycin and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxicity and reduced renal clearance of renally eliminated drugs.
What to do
Monitor serum creatinine and phosphate regularly, and adjust doses of both drugs for declining renal function. Consider tenofovir alafenamide if renal impairment develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bleomycin
- Adenovirus types 4 and 7 live + Bleomycin Contraindicated
- Bleomycin + Brentuximab Contraindicated
- Bleomycin + Brentuximab vedotin Contraindicated
- Bleomycin + Dengue vaccine Major
- Bleomycin + Trastuzumab deruxtecan Major
- Bleomycin + Cholera vaccine Moderate
Frequently asked questions
Can I take Bleomycin with Tenofovir df?
MediHelp rates the interaction as moderate. Bleomycin and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bleomycin is renally eliminated and can be nephrotoxic, while tenofovir is also cleared by the kidney and can cause tubular injury. Reduced renal function may increase exposure to both drugs and worsen toxicity.
How serious is the interaction between Bleomycin and Tenofovir df?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and phosphate regularly, and adjust doses of both drugs for declining renal function. Consider tenofovir alafenamide if renal impairment develops.
What other medicines interact with Bleomycin?
MediHelp also lists interactions of Bleomycin with, for example, Adenovirus types 4 and 7 live, Brentuximab, Brentuximab vedotin. The full list is on the Bleomycin page.
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