Drug interactions
Bleomycin + Tenofovir disoproxil
Severity: Moderate
Bleomycin and Tenofovir disoproxil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bleomycin is eliminated largely by the kidneys and can cause renal toxicity. Kidney impairment may raise tenofovir concentrations, and reduced bleomycin clearance may increase pulmonary toxicity. Overall evidence for a direct interaction is limited.
What this interaction means in plain words
Bleomycin and Tenofovir disoproxil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible additive renal injury leading to reduced renal elimination of both drugs; a direct transporter interaction is not established.
What to do
Check renal function before and during bleomycin cycles and adjust doses of both drugs for creatinine clearance. Watch for signs of bleomycin pulmonary toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bleomycin
- Adenovirus types 4 and 7 live + Bleomycin Contraindicated
- Bleomycin + Brentuximab Contraindicated
- Bleomycin + Brentuximab vedotin Contraindicated
- Bleomycin + Dengue vaccine Major
- Bleomycin + Trastuzumab deruxtecan Major
- Bleomycin + Cholera vaccine Moderate
Frequently asked questions
Can I take Bleomycin with Tenofovir disoproxil?
MediHelp rates the interaction as moderate. Bleomycin and Tenofovir disoproxil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bleomycin is eliminated largely by the kidneys and can cause renal toxicity. Kidney impairment may raise tenofovir concentrations, and reduced bleomycin clearance may increase pulmonary toxicity. Overall evidence for a direct interaction is limited.
How serious is the interaction between Bleomycin and Tenofovir disoproxil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check renal function before and during bleomycin cycles and adjust doses of both drugs for creatinine clearance. Watch for signs of bleomycin pulmonary toxicity.
What other medicines interact with Bleomycin?
MediHelp also lists interactions of Bleomycin with, for example, Adenovirus types 4 and 7 live, Brentuximab, Brentuximab vedotin. The full list is on the Bleomycin page.
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