Drug interactions
Blinatumomab + Valproic acid
Severity: Moderate
Blinatumomab and Valproic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Blinatumomab causes a transient cytokine release at treatment start that can suppress CYP450 enzymes. Exposure to some co-medications may rise temporarily, and valproate has a narrow therapeutic range, so toxicity is possible, although valproate is mainly glucuronidated.
What this interaction means in plain words
Blinatumomab and Valproic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Blinatumomab belongs to Oncology; Valproic acid belongs to Central Nervous System.
Why it happens
Cytokine-mediated transient suppression of CYP450 enzymes after blinatumomab infusion starts.
What to do
Monitor valproate levels and signs of toxicity such as sedation, tremor and confusion during the first days of each blinatumomab cycle. Adjust the valproate dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Valproic acid
- Ertapenem + Valproic acid Contraindicated
- Imipenem / cilastatin / relebactam + Valproic acid Contraindicated
- Imipenem / cilastatin + Valproic acid Contraindicated
- Meropenem / vaborbactam + Valproic acid Contraindicated
- Meropenem + Valproic acid Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Valproic acid Major
Other interactions of Blinatumomab
- Blinatumomab + Carbamazepine Moderate
- Blinatumomab + Cyclosporin Moderate
- Blinatumomab + Ethosuximide Moderate
- Blinatumomab + Phenytoin Moderate
- Blinatumomab + Quinidine Moderate
- Blinatumomab + Quinine Moderate
Frequently asked questions
Can I take Blinatumomab with Valproic acid?
MediHelp rates the interaction as moderate. Blinatumomab and Valproic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Blinatumomab causes a transient cytokine release at treatment start that can suppress CYP450 enzymes. Exposure to some co-medications may rise temporarily, and valproate has a narrow therapeutic range, so toxicity is possible, although valproate is mainly glucuronidated.
How serious is the interaction between Blinatumomab and Valproic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor valproate levels and signs of toxicity such as sedation, tremor and confusion during the first days of each blinatumomab cycle. Adjust the valproate dose as needed.
What other medicines interact with Valproic acid?
MediHelp also lists interactions of Valproic acid with, for example, Ertapenem, Imipenem / cilastatin / relebactam, Imipenem / cilastatin. The full list is on the Valproic acid page.
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