Drug interactions
Blinatumomab + Warfarin
Severity: Moderate
Blinatumomab and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Blinatumomab causes transient cytokine release that can suppress CYP450 enzyme activity. Warfarin levels and anticoagulant effect may rise, increasing bleeding risk, mainly at treatment initiation.
What this interaction means in plain words
Blinatumomab and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Blinatumomab belongs to Oncology; Warfarin belongs to Cardiovascular.
Why it happens
Cytokine release (e.g. IL-6) temporarily downregulates hepatic CYP450 enzymes, reducing warfarin metabolism.
What to do
Monitor INR more frequently during the first days of the first cycle and when restarting after interruption. Adjust warfarin dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Blinatumomab
- Blinatumomab + Carbamazepine Moderate
- Blinatumomab + Cyclosporin Moderate
- Blinatumomab + Ethosuximide Moderate
- Blinatumomab + Phenytoin Moderate
- Blinatumomab + Quinidine Moderate
- Blinatumomab + Quinine Moderate
Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Frequently asked questions
Can I take Blinatumomab with Warfarin?
MediHelp rates the interaction as moderate. Blinatumomab and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Blinatumomab causes transient cytokine release that can suppress CYP450 enzyme activity. Warfarin levels and anticoagulant effect may rise, increasing bleeding risk, mainly at treatment initiation.
How serious is the interaction between Blinatumomab and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor INR more frequently during the first days of the first cycle and when restarting after interruption. Adjust warfarin dose accordingly.
What other medicines interact with Blinatumomab?
MediHelp also lists interactions of Blinatumomab with, for example, Carbamazepine, Cyclosporin, Ethosuximide. The full list is on the Blinatumomab page.
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