Drug interactions
Bortezomib + Cyclosporin
Severity: Minor
Bortezomib and Cyclosporin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine may increase bortezomib exposure because bortezomib is metabolized by CYP3A4. This could worsen peripheral neuropathy, cytopenias and gastrointestinal toxicity.
What this interaction means in plain words
Bortezomib and Cyclosporin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bortezomib belongs to Oncology; Cyclosporin belongs to Miscellaneous.
Why it happens
Cyclosporine inhibits CYP3A4, reducing bortezomib clearance.
What to do
Monitor for neuropathy, thrombocytopenia and other bortezomib toxicity, and reduce the bortezomib dose if these occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Bortezomib
- Apalutamide + Bortezomib Major
- Bortezomib + Carbamazepine Major
- Bortezomib + Etrasimod Major
- Bortezomib + Fosphenytoin Major
- Bortezomib + Idelalisib Major
- Bortezomib + Lonafarnib Major
Frequently asked questions
Can I take Bortezomib with Cyclosporin?
MediHelp rates the interaction as minor. Bortezomib and Cyclosporin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cyclosporine may increase bortezomib exposure because bortezomib is metabolized by CYP3A4. This could worsen peripheral neuropathy, cytopenias and gastrointestinal toxicity.
How serious is the interaction between Bortezomib and Cyclosporin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for neuropathy, thrombocytopenia and other bortezomib toxicity, and reduce the bortezomib dose if these occur.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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