Drug interactions
Bortezomib + Diazepam
Severity: Minor
Bortezomib and Diazepam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bortezomib is metabolized by CYP2C19 and other enzymes and might modestly affect diazepam levels, but there is no good clinical evidence of a meaningful effect. Any change is expected to be small.
What this interaction means in plain words
Bortezomib and Diazepam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bortezomib belongs to Oncology; Diazepam belongs to Musculoskeletal.
Why it happens
Possible competition at CYP2C19; not well established clinically.
What to do
No dose change is usually required; monitor for excess sedation in patients on both drugs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diazepam
Other interactions of Bortezomib
- Apalutamide + Bortezomib Major
- Bortezomib + Carbamazepine Major
- Bortezomib + Etrasimod Major
- Bortezomib + Fosphenytoin Major
- Bortezomib + Idelalisib Major
- Bortezomib + Lonafarnib Major
Frequently asked questions
Can I take Bortezomib with Diazepam?
MediHelp rates the interaction as minor. Bortezomib and Diazepam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bortezomib is metabolized by CYP2C19 and other enzymes and might modestly affect diazepam levels, but there is no good clinical evidence of a meaningful effect. Any change is expected to be small.
How serious is the interaction between Bortezomib and Diazepam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually required; monitor for excess sedation in patients on both drugs.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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