Drug interactions
Bortezomib + Erythromycin
Severity: Moderate
Bortezomib and Erythromycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bortezomib is metabolized partly by CYP3A4, and erythromycin may modestly increase its exposure. This could raise the risk of neuropathy, cytopenias and gastrointestinal toxicity.
What this interaction means in plain words
Bortezomib and Erythromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bortezomib belongs to Oncology; Erythromycin belongs to Anti Bacterial.
Why it happens
Inhibition of CYP3A4 by erythromycin reduces bortezomib clearance.
What to do
Monitor for neuropathy, thrombocytopenia and GI toxicity, and reduce the bortezomib dose if toxicity appears. Consider a non-inhibiting antibiotic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Bortezomib
- Apalutamide + Bortezomib Major
- Bortezomib + Carbamazepine Major
- Bortezomib + Etrasimod Major
- Bortezomib + Fosphenytoin Major
- Bortezomib + Idelalisib Major
- Bortezomib + Lonafarnib Major
Frequently asked questions
Can I take Bortezomib with Erythromycin?
MediHelp rates the interaction as moderate. Bortezomib and Erythromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bortezomib is metabolized partly by CYP3A4, and erythromycin may modestly increase its exposure. This could raise the risk of neuropathy, cytopenias and gastrointestinal toxicity.
How serious is the interaction between Bortezomib and Erythromycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for neuropathy, thrombocytopenia and GI toxicity, and reduce the bortezomib dose if toxicity appears. Consider a non-inhibiting antibiotic.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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