Drug interactions
Bortezomib + Imipramine
Severity: Minor
Bortezomib and Imipramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bortezomib is a weak inhibitor of CYP2C19 in vitro, which could slightly raise imipramine levels. A clinically significant change has not been well demonstrated. The tricyclic's effects may be more pronounced in patients with other risk factors.
What this interaction means in plain words
Bortezomib and Imipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bortezomib belongs to Oncology; Imipramine belongs to Central Nervous System.
Why it happens
Possible weak inhibition of CYP2C19-mediated imipramine metabolism by bortezomib.
What to do
No empirical dose change is needed. Watch for anticholinergic, sedative or cardiac effects of imipramine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Bortezomib
- Apalutamide + Bortezomib Major
- Bortezomib + Carbamazepine Major
- Bortezomib + Etrasimod Major
- Bortezomib + Fosphenytoin Major
- Bortezomib + Idelalisib Major
- Bortezomib + Lonafarnib Major
Frequently asked questions
Can I take Bortezomib with Imipramine?
MediHelp rates the interaction as minor. Bortezomib and Imipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bortezomib is a weak inhibitor of CYP2C19 in vitro, which could slightly raise imipramine levels. A clinically significant change has not been well demonstrated. The tricyclic's effects may be more pronounced in patients with other risk factors.
How serious is the interaction between Bortezomib and Imipramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed. Watch for anticholinergic, sedative or cardiac effects of imipramine.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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