Drug interactions
Bortezomib + Istradefylline
Severity: Minor
Bortezomib and Istradefylline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At 40 mg daily istradefylline weakly inhibits CYP3A4 and may increase exposure to CYP3A4 substrates. Bortezomib is partly metabolized by CYP3A4, so toxicity could increase modestly, whereas the 20 mg dose has not shown this effect.
What this interaction means in plain words
Bortezomib and Istradefylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bortezomib belongs to Oncology; Istradefylline belongs to Central Nervous System.
Why it happens
Istradefylline at higher doses weakly inhibits CYP3A4, slightly decreasing bortezomib clearance.
What to do
Monitor for bortezomib adverse effects, especially neuropathy and cytopenias, if istradefylline 40 mg daily is used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bortezomib
- Apalutamide + Bortezomib Major
- Bortezomib + Carbamazepine Major
- Bortezomib + Etrasimod Major
- Bortezomib + Fosphenytoin Major
- Bortezomib + Idelalisib Major
- Bortezomib + Lonafarnib Major
Other interactions of Istradefylline
Frequently asked questions
Can I take Bortezomib with Istradefylline?
MediHelp rates the interaction as minor. Bortezomib and Istradefylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. At 40 mg daily istradefylline weakly inhibits CYP3A4 and may increase exposure to CYP3A4 substrates. Bortezomib is partly metabolized by CYP3A4, so toxicity could increase modestly, whereas the 20 mg dose has not shown this effect.
How serious is the interaction between Bortezomib and Istradefylline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bortezomib adverse effects, especially neuropathy and cytopenias, if istradefylline 40 mg daily is used.
What other medicines interact with Bortezomib?
MediHelp also lists interactions of Bortezomib with, for example, Apalutamide, Carbamazepine, Etrasimod. The full list is on the Bortezomib page.
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