Drug interactions
Bortezomib + Ivosidenib
Severity: Moderate
Bortezomib and Ivosidenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib induces CYP3A4 and may lower bortezomib concentrations. This could reduce anti-myeloma efficacy. Ivosidenib can also prolong the QT interval, but that is not the issue for this pair.
What this interaction means in plain words
Bortezomib and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bortezomib belongs to Oncology; Ivosidenib belongs to Oncology.
Why it happens
Ivosidenib induces CYP3A4, increasing bortezomib metabolism.
What to do
Monitor for reduced disease response; consider alternative therapy if effect is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bortezomib
- Apalutamide + Bortezomib Major
- Bortezomib + Carbamazepine Major
- Bortezomib + Etrasimod Major
- Bortezomib + Fosphenytoin Major
- Bortezomib + Idelalisib Major
- Bortezomib + Lonafarnib Major
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Bortezomib with Ivosidenib?
MediHelp rates the interaction as moderate. Bortezomib and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivosidenib induces CYP3A4 and may lower bortezomib concentrations. This could reduce anti-myeloma efficacy. Ivosidenib can also prolong the QT interval, but that is not the issue for this pair.
How serious is the interaction between Bortezomib and Ivosidenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced disease response; consider alternative therapy if effect is lost.
What other medicines interact with Bortezomib?
MediHelp also lists interactions of Bortezomib with, for example, Apalutamide, Carbamazepine, Etrasimod. The full list is on the Bortezomib page.
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