Drug interactions
Bortezomib + Larotrectinib
Severity: Minor
Bortezomib and Larotrectinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib may weakly inhibit CYP3A4, and any rise in bortezomib exposure is likely small. No clinical interaction has been documented.
What this interaction means in plain words
Bortezomib and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bortezomib belongs to Oncology; Larotrectinib belongs to Oncology.
Why it happens
Larotrectinib may weakly inhibit CYP3A4, which could slightly reduce bortezomib clearance.
What to do
No dose adjustment is needed. Monitor for the usual bortezomib toxicities.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Bortezomib and Larotrectinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Bortezomib
- Apalutamide + Bortezomib Major
- Bortezomib + Carbamazepine Major
- Bortezomib + Etrasimod Major
- Bortezomib + Fosphenytoin Major
- Bortezomib + Idelalisib Major
- Bortezomib + Lonafarnib Major
Other interactions of Larotrectinib
Frequently asked questions
Can I take Bortezomib with Larotrectinib?
MediHelp rates the interaction as minor. Bortezomib and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib may weakly inhibit CYP3A4, and any rise in bortezomib exposure is likely small. No clinical interaction has been documented.
How serious is the interaction between Bortezomib and Larotrectinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor for the usual bortezomib toxicities.
What other medicines interact with Bortezomib?
MediHelp also lists interactions of Bortezomib with, for example, Apalutamide, Carbamazepine, Etrasimod. The full list is on the Bortezomib page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
