Drug interactions
Bortezomib + Nifedipine
Severity: Minor
Bortezomib and Nifedipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bortezomib is partly metabolized by CYP3A4, so nifedipine could slightly increase its exposure, though the effect is expected to be small. Bortezomib can also cause hypotension, which may add to nifedipine.
What this interaction means in plain words
Bortezomib and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bortezomib belongs to Oncology; Nifedipine belongs to Cardiovascular.
Why it happens
Weak CYP3A4 inhibition by nifedipine plus additive hypotensive effects.
What to do
No dose change is needed routinely. Monitor blood pressure and bortezomib toxicity such as neuropathy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nifedipine
Other interactions of Bortezomib
- Apalutamide + Bortezomib Major
- Bortezomib + Carbamazepine Major
- Bortezomib + Etrasimod Major
- Bortezomib + Fosphenytoin Major
- Bortezomib + Idelalisib Major
- Bortezomib + Lonafarnib Major
Frequently asked questions
Can I take Bortezomib with Nifedipine?
MediHelp rates the interaction as minor. Bortezomib and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bortezomib is partly metabolized by CYP3A4, so nifedipine could slightly increase its exposure, though the effect is expected to be small. Bortezomib can also cause hypotension, which may add to nifedipine.
How serious is the interaction between Bortezomib and Nifedipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed routinely. Monitor blood pressure and bortezomib toxicity such as neuropathy.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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